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Variation in breast cancer risk in BRCA1 and BRCA2 mutation carriers

Genetic testing for BRCA1 and BRCA2 (BRCA1/2) mutations can provide important information for women who are concerned about their breast and ovarian cancer risks and need to make relevant prevention and medical management decisions. However, lifetime risks of breast cancer in individual BRCA1/2 mutation carriers have been confusing to apply in clinical decision-making. Published risk estimates vary significantly and are very dependent on the characteristics of the population under study. Recently, Begg et al. estimated cancer risks in a population-based study of BRCA1/2 mutation carriers. Here, we discuss the clinical decision-making implications of this research in the context of risk factors that may influence risk estimates in BRCA1/2 mutation carriers.
[in Breast Cancer Research]

Interaction between Calpain-5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity.

Background: Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed. Our objective was to investigate the possibility of the existence of a crosstalk between the Calpain-10 homologue Calpain-5 and nuclear receptors of the peroxisome proliferator-activated receptors family. Methods: The study sample comprise 1953 individuals, 725 obese (defined as body mass index [greater than or equal to] 30) and 1228 non obese subjects. We performed cross-sectional, genetic association study and gene-gene interaction analysis. Results: In the monogenic analysis, only the peroxisome proliferator-activated receptor delta (PPARD) gene was associated with obesity (OR=1.43[1.04-1.97], p=0.027). In addition, we have found a significant interaction between CAPN5 and PPARD genes (p=0.038) that reduces the risk for obesity in a 55%. Conclusions: Our results suggest that CAPN5 and PPARD gene products may also interact in vivo.
[in Cardiovascular Diabetology]

Plans to harmonise data collection and reporting of TB/HIV collaborative activities

[in Aidsmap]

TopAbstracts in Alzheimer's 07/24/2008

[in Doctor's Guide: Alzheimer's]

Do certain foods trigger your heartburn?

There is an ongoing debate among both professionals and patients as to whether specific foods can trigger heartburn. Studies have been done and other studies re-examined, with the conclusion in...
[in About.com: Heartburn]

Extended-Dose Nevirapine May Reduce Risk of Mother-to-Infant HIV Transmission in Developing Countries

[in Doctor's Guide: AIDS & HIV]

CANADA: Trend Reversing Itself? B.C. Report Suggests Fewer Teens Are Having Sex

Results from the latest survey of British Columbia teenagers show the number of youths who say they have had sex dropped by a third between 1992 and 2003.
[in Aegis]

ISENTRESS(r) (raltegravir), Merck's First in Class Integrase Inhibitor, Suppressed HIV-1 Viral Load and Increased CD4 Cell Counts...

ISENTRESS(r) (raltegravir), Merck's First in Class Integrase Inhibitor, Suppressed HIV-1 Viral Load and Increased CD4 Cell Counts through 48-Weeks in Treatment-Experienced Adult Patients When Taken with Other Anti-HIV Medicines, New England Journal of Medicine Reports Business Wire - July 23, 2008 [A href='http://www.aegis.org/news/bw/2008 ...
[in Aegis.org: HIV/AIDS News]

Africa: Homophobia fuelling the spread of HIV

Africa: Homophobia fuelling the spread of HIV UN Integrated Regional Information Network - July 23, 2008 http://www.aegis.org/news/irin/2008/IR080734.html LIMBÉ, 23 July 2008 (IRIN) - The persistent and increasing outbreaks of violence against me ...
[in Aegis.org: HIV/AIDS News]

Researchers Identify Gene Responsible for Congenital Tufting Enteropathy (CTE)

[in Doctor's Guide: General]