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Early treatment is key to combating hepatitis C virus

Canadian researchers have shown that patients who receive early treatment for Hepatitis C virus (HCV) within the first months following an infection, develop a rapid poly-functional immune response against HCV similar to when infection is erradicted spontaneously, according to a new study published in the Journal of Virology. Therefore, early treatment can restore immune response against HCV and help eliminate the virus rapidly. This new discovery of the mechanisms of viral eradication could contribute to the development of new treatments.
[in PhysOrg.com]

Forum features update on next-generation particle accelerator

The particle accelerator known as the Energy Recovery Linac (ERL) -- now in planning stages at Cornell -- would open doors to new research in fields from materials science to biochemistry, said Georg Hoffstaetter in a lecture to faculty and staff in Cornell's Research Division, July 31. But if the ERL's scientific scope is wide, he said, its strength would be in shedding new light on the very, very small.
[in PhysOrg.com]

Molecular bridge serves as a tether for a cell's nucleus

(PhysOrg.com) -- A cell's nucleus - home of it its most precious contents is a delicate envelope that, without support, is barely able to withstand the forces that keep it in place. Now, researchers have discovered a network of molecules in the nuclear membrane that provide the nucleus with rigidity and also facilitate a previously undiscovered form of communication between the cell`s nucleus and its cytoplasm.
[in PhysOrg.com]

2.5 million-year-old mastodon unearthed in Romania

(AP) -- Miners in Romania have unearthed the skeleton of a 2.5 million-year-old mastodon, believed to be one of the best preserved in Europe, a local official said Friday.
[in PhysOrg.com]

Talk about "eating your own"-- KS politics at thei

[in St. Louis Post-Dispatch: Science & Medicine]

ViewWise Enterprise Edition: Integrated Document Management / Email Archival Solutions

[in ITPapers.com - Metallurgy]

Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction

Nucleic Acids Research, Vol. 33, No. 8. (2005), pp. 2765-2765.
[in CiteULike: Everyone's library]

Targeted expression of Cre recombinase in macrophages and osteoclasts in transgenic mice

genesis, Vol. 41, No. 3. (2005), pp. 138-145.

To develop specific conditional gene ablation in the hematopoietic myeloid-osteoclast lineage, transgenic mice expressing Cre recombinase under the control of the CD11b promotor were generated on the C57BL/6 background. The cellular specificity of Cre activity following recombination was quantified in the Z/EG reporter transgenic mice by FACS analysis with lineage-specific markers and EGFP coexpression. A high degree of recombination, as evidenced by EGFP-positive cells, was demonstrated in macrophages and granulocytes of bone marrow and spleen by the presence of double-positive cells CD11b/EGFP and Gr1/EGFP, respectively. Interestingly, the peritoneal macrophage population showed almost complete DNA recombination at large. Most important, mature osteoclast cells derived from the double transgenic bone marrow and spleen progenitors were EGFP-positive. Hence, these CD11b-Cre mice will provide a unique tool to unravel novel gene function and activities involved during osteoclast and macrophage differentiation and maturation processes. genesis 41:138-145, 2005. © 2005 Wiley-Liss, Inc.
[in CiteULike: Everyone's library]

A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration

Nature Methods, Vol. 2, No. 6. (20 May 2005), pp. 419-426.
[in CiteULike: Everyone's library]

Aging, Inflammation, and Cancer

August 08 2008 | Permanent Link
Less chronic inflammation, less cancer: "Cancer is generally recognized as an age-related disease. In fact, incidence and mortality rates of most human cancers increase consistently with age up to 90 years, but they plateau and decline thereafter. A low-grade systemic inflammation characterizes ageing and this pro-inflammatory status underlies biological mechanisms responsible for age-related inflammatory diseases. On the other hand, clinical and epidemiological studies show a strong association between chronic infection, inflammation and cancer and indicate that even in tumours not directly linked to pathogens, the microenvironment is characterized by the presence of a smouldering inflammation, fuelled primarily by stromal leukocytes. ... Centenarians are characterized by a higher frequency of genetic markers associated with better control of inflammation. The reduced capacity of centenarians to mount inflammatory responses appears to exert a protective effect towards the development of those age-related pathologies having a strong inflammatory pathogenetic component, including cancer. All in all, centenarians seem to carry a genetic background with a peculiar resistance to cancer which is also an anti-inflammatory profile."
[in Longevity Meme News Commentary]